Updating the beers criteria for potentially inappropriate
Examples include some benzodiazepines (e.g., diazepam, chlordiazepoxide), tertiary amine antidepressants (e.g., amitriptyline, imipramine), antipsychotics (e.g., chlorpromazine, thioridazine, risperidone), and opioid analgesics (e.g., meperidine, propoxyphene).
Twenty percent (20%) of those ADR reports in patients over 65 describe patients receiving PHENERGAN (promethazine) and developing mental status changes such as agitation, “jitters,” and restlessness.
However, this is often not the case, as these physiologic changes to the kidneys decrease renal clearance of drugs necessitating a dose adjustment.
Many drugs produce active metabolites in clinically significant concentrations.
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